Leaf Systems®

Leaf Systems® International Limited is a new contract development business specialising in the expression and production of proteins, metabolites and complex natural products for research and bio-medical applications using a proprietary, transient expression technology.

Business Overview

Leaf Systems uses the proprietary Hypertrans® expression technologies developed by Prof.George Lomonossoff at the John Innes Centre, UK. The Hypertrans system allows for the simultaneous production of multiple gene products in a controlled and coordinated manner within the tissues of plants. Using gene synthesis and modular vectors, new products can be developed, validated, scaled and produced very quickly. Potential applications of the technology include:

  • Production of complex proteins, such as antibodies or enzymes for research applications.
  • Production of antigens including virus-like particles for vaccine development or nano-technology.
  • Rapid prototyping and surge production in response to external circumstances.
  • Metabolic pathway engineering to generate complex biochemicals that are difficult or impossible to synthesise chemically or are only found in rare species or trace amounts in nature.

Leaf Systems is employing state of the art containment facilities to produce and engineer its feedstock plants and has industry standard downstream processing capabilities to ensure production quality and bio-security.


Leaf Systems works with companies as a contract development organisation to develop and scale the production of their products or intermediates. We also work alongside academic scientists to translate their science into scalable processes or to develop new enabling technologies, including as a collaborator on grants. Leaf Systems has SME status and is available to participate in translational research and development consortia, including EU framework programs.

Find us.

Leaf Systems International Limited,
Building 7, Zone 2,
Norwich Research Park,
Colney Lane, Norwich,

Call us

+44 (0) 1603 859 379

Email us.